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FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., 3 Treatments

4.5 4.5 out of 5 stars 13,810 ratings
Amazon's Choice highlights highly rated, well-priced products available to ship immediately.
Amazon's Choice in Dog Flea Drops by Frontline
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$30.02 with 27 percent savings $30.02 per Count
Typical price: $40.99

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3 Count
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Purchase options and add-ons

Brand Frontline
Item Form Stick
Scent Unscented
Age Range (Description) All Life Stages
Item Weight 1.6 Ounces
Active Ingredients fipronil and (S)-methoprene
Item Volume 302.4 Milliliters
Target Species Dog
Allergen Information Abalone Free
Dog Breed Size Large

About this item

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
  • Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
  • Trusted by pet owners for over 20 years**, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus.

Customer ratings by feature

Easy to use
4.2 4.2
Accuracy
3.9 3.9
Value for money
3.4 3.4
Easy to remove
3.2 3.2
See all reviews

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FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., 3 Treatments
$30.02 ($30.02/Count)
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FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments
$30.02 ($10.01/Count)
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FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs., 3 Treatments
$30.02 ($588.63/Fluid Ounce)
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From the brand

Previous page
  2. Frontline brand products logo. Protect your dog or cat with Frontline Plus flea and tick prevention

    THE #1 NAME IN FLEA & TICK PROTECTION*

    FRONTLINE Brand Products are effective topical solutions designed to help protect dogs and cats from fleas and ticks. FRONTLINE Plus and FRONTLINE Gold have formulas for dogs or cats. FRONTLINE Shield, with added mosquito repellency, is for dogs only.

  3. Frontline Plus for Dogs and Puppies has been trusted by pet owners for over twenty years
    Frontline Plus flea and tick medicine for small dogs six topical nonprescription applicators pack
    Frontline Plus flea and tick medicine for medium dogs six topical nonprescription applicators pack
    Frontline Plus flea and tick medicine for large dogs pack of six topical nonprescription applicators

    FRONTLINE Plus for Dogs

    Visit the Store

  4. Frontline Shield is formulated to repel ticks and mosquitoes. repelente de mosquitos para perros
    Frontline Shield flea and tick treatment and mosquito repellent for small dogs six month pack
    Frontline Shield flea and tick treatment and mosquito repellent for medium dogs six month pack
    Frontline Shield flea and tick treatment and mosquito repellent for large dogs six month pack

    FRONTLINE Shield for Dogs

    Visit the Store

  5. Frontline Plus for Cats and Kittens has been trusted by pet owners for over twenty years
    Frontline Plus flea and tick monthly prevention topical for cats and kittens three doses
    Frontline Plus flea and tick monthly prevention topical for cats and kittens six doses
    Frontline Plus flea and tick monthly prevention topical for cats and kittens eight doses

    FRONTLINE Plus for Cats

    Visit the Store

  6. Frontline comes in an easy to use applicator. Use spring summer fall winter to kill fleas and ticks
    Frontline Gold flea and tick treatment for small dogs six month supply pack
    Frontline Gold flea and tick treatment for medium dogs six month supply pack
    Frontline Gold flea and tick treatment for large dogs six month supply pack

    FRONTLINE Gold for Dogs

    Visit the Store

  7. Frontline comes in an easy to use applicator. Apply during all seasons to prevent fleas and ticks
    Frontline Gold for Cats three month supply pack. suministro de tratamiento para tres meses
    Frontline Gold for Cats six month supply pack. suministro de tratamiento para seis meses
    Frontline Gold flea and tick protection for cats and kittens

    FRONTLINE Gold for Cats

    Visit the Store

  8. Frontline brands break the flea life cycle by eradicating adult fleas eggs and larvae. Treat monthly

  9. What is FRONTLINE?

    FRONTLINE Brand Products are effective, easy-to-apply topical flea & tick preventives. FRONTLINE Plus and FRONTLINE Gold have formulas for dogs or cats. FRONTLINE Shield is for dogs only. All FRONTLINE Brand Products feature waterproof formulas that last a full 30 days.

    Why should I protect my dog or cat from fleas & ticks?

    Fleas & ticks are a year-round threat. FRONTLINE Brand Products help protect dogs or cats from these pests and monthly use can help prevent infestations.

Next page

From the manufacturer

Smiling man playing fetch outside with healthy dog. Frontline Plus awarded Newsweek most trusted
Frontline Plus has been trusted by pet owners for over 20 years and kills fleas and chewing lice
Answers to frequently asked questions about Frontline flea and tick prevention and treatment plans

How to Apply FRONTLINE Plus for Dogs

Step one woman reading instructions on pack before applying flea and tick non prescription treatment

Step two woman holding applicator upright and away from her face before opening by snapping off tip

Step three prep dog for flea treatment application by using fingers to part fur so skin is visible

Step four place the open applicator to dogs skin and squeeze out all contents on dog

Read full instructions on packaging before use. Shown here: Size Large 45-88 lbs.

Use scissors to separate one blister. Hold applicator upright with foil side toward you and snap applicator tip off.

Part dog’s hair between shoulder blades until skin is visible.

Place applicator tip directly against exposed skin and apply entire contents directly to the skin. Do not apply on top of hair.

Pack of Frontline Plus for small dog breeds tratamiento de pulgas y garrapatas para perros pequenos Pack of Frontline Plus for medium dog breeds medicina para matar pulgas y garrapatas Pack of Frontline Plus for large dog breeds prevención de pulgas y garrapatas para perros grandes Pack of Frontline Plus for xl dog breeds control de pulgas y garrapatas para perros extra grandes Frontline Plus Cat
FRONTLINE Plus for Small Dogs FRONTLINE Plus for Medium Dogs FRONTLINE Plus for Large Dogs FRONTLINE Plus for X-Large Dogs FRONTLINE Plus for Cats
Customer Reviews
4.4 out of 5 stars
80,777
4.4 out of 5 stars
21,084
4.4 out of 5 stars
80,777
4.5 out of 5 stars
13,810
4.3 out of 5 stars
43,634
Price $55.29 $55.29 $55.29 $55.29 $55.29
Recommended pet size 5 to 22 pounds 23 to 44 pounds 45 to 88 pounds 89 to 132 pounds Cats and kittens over 1.5 pounds
Kills adult fleas, flea eggs, and flea larvae ✓ ✓ ✓ ✓ ✓
Kills ticks and chewing lice ✓ ✓ ✓ ✓ ✓
Minimum age of pet for use Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Cats and kittens 8 weeks and older
Available sizes 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose
Do not use on cats Do not use on cats Do not use on cats Do not use on cats For use on cats only

Product guides and documents

User Guide (PDF)

Product information

Feedback

FRONTLINE

FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., 3 Treatments

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Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 5.75 x 0.75 x 4.5 inches; 1.6 ounces
  • Manufacturer recommended age ‏ : ‎ 1 month and up
  • Item model number ‏ : ‎ 72220
  • Department ‏ : ‎ Flea & Tick
  • Date First Available ‏ : ‎ May 30, 2004
  • Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health
  • ASIN ‏ : ‎ B0002J1FP8
  • Country of Origin ‏ : ‎ France
  • Customer Reviews:
    4.5 4.5 out of 5 stars 13,810 ratings

Looking for specific info?

Product Description

Product Description

Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE®. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**— FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: *Data on file at Boehringer Ingelheim. **Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.

Brand Story

By Frontline Plus

Top Brand: Frontline

Highly Rated
100K+ customers rate items from this brand highly
Trending
100K+ orders for this brand in past 3 months
Low Returns
Customers usually keep items from this brand

Important information

Safety Information

KEEP OUT OF REACH OF CHILDREN. WARNING: PRECAUTIONARY STATEMENTS - HAZARDS TO HUMANS: WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid Contact with skin. Harmful if swallowed. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash clothing that may have come in contact with the product before reuse. HAZARDS TO DOMESTIC ANIMALS: For external use on dogs ONLY. Do not use on animals other than dogs. Do not use on dogs under 9 weeks of age or weighing less than 5 lbs. Individual sensitivities may occur after using ANY pesticide product. Dogs may experience some temporary irritation at the site of product application. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of sensitivity occur and persist, contact a veterinarian immediately. If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products. Consult a veterinarian for guidance on use against Sarcoptes mites. This product is not a substitute for a prescribed heartworm preventative.nCall 1-888-637-4251, for assistance. PHYSICAL OR CHEMICAL HAZARDS: Do not allow this product to come in contact with an oxidizing agent, as a hazardous chemical reaction may occur Harmful if swallowed. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid contact with skin. Wear (specify appropriate protective eyewear such as goggles, face shield, or safety glasses). Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.

Ingredients

Fipronil (9.8%)|(S)-Methoprene (8.8%)

Directions

Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product. Do not apply to dogs weighing less than 89 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month. Frequency Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

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FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., 3 Treatments
FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., 3 Treatments
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Apex Plus Flea and Tick Prevention for Dogs | X-Large (89-132 lbs) | 3-Month Supply | Dog Flea and Tick Treatment | 24-Hour Activation, Waterproof, 30-Day Protection
Apex Plus Flea and Tick Prevention for Dogs | X-Large (89-132 lbs) | 3-Month Supply | Dog Flea and Tick Treatment | 24-Hour Activation, Waterproof, 30-Day Protection
Details
Added to Cart
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Price-27% $30.02
Typical: $40.99		$19.97-20% $37.59
List: $46.99		-15% $46.74
Typical: $54.99		$54.99$14.99
Delivery
Get it as soon as Tuesday, May 14
Get it as soon as Tuesday, May 14
Get it as soon as Tuesday, May 14
Get it as soon as Tuesday, May 14
Get it as soon as Wednesday, May 15
Get it as soon as Monday, May 13
Customer Ratings
4.54.5 out of 5 stars13,810
4.04.0 out of 5 stars551
4.44.4 out of 5 stars387
4.54.5 out of 5 stars567
4.54.5 out of 5 stars117
4.04.0 out of 5 stars52
Easy to use
4.2
4.3
4.2
4.4
4.7
3.8
Value for money
3.4
3.7
3.0
3.8
3.8
3.2
Scent
3.2
4.3
3.3
4.4
3.0
—
Flavor
3.1
3.1
3.0
2.4
—
2.3
Sold By
Amazon.com
TevraBrands
Amazon.com
Amazon.com
Amazon.com
Apex Animal Health
target audience
Dogs
Extra Large Dogs
Dog
Adult
Adult
—
age range
All Life Stages
All Life Stages
All Life Stages
All Life Stages
All Life Stages
Over 8 Weeks of Age
scent
Unscented
Topical
Topical
No Scent
No Scent
—
form
Stick
Drops
Stick
Stick
Stick
Drops
volume
302.4 milliliters
0.41 fluid ounces
18 milliliters
8.04 milliliters
12.06 milliliters
—
active ingredients
fipronil and (S)-methoprene
Fipronil
Fipronil, Permethrin, Pyriproxyfen
Fipronil, (S)-methoprene, Pyriproxyfen
Fipronil, (S)-methoprene, Pyriproxyfen
—

Customer reviews

4.5 out of 5 stars
4.5 out of 5
13,810 global ratings

Customers say

Customers like the quality and value of the pet pest control. For example, they mention it's a great product, works well, and is the best value for money. Some are also satisfied with ease of use. That said, opinions are mixed on flea/tick control, performance, effect on skin, and durability.

AI-generated from the text of customer reviews

366 customers mention268 positive98 negative

Customers like the value of the pet pest control. They say it's the best value for money, works well, and is cost efficient.

"...I'm happy I did! No more fleas! Price is affordable too! Thanks for that!" Read more

"works great always buy this product good price" Read more

"...And there’s barely an odor. But the price is outrageously high when you have several animals. This particular product was for my 120 lb. dog...." Read more

"...Pets are protected at a better price." Read more

237 customers mention197 positive40 negative

Customers like the quality of the pet pest control. They mention that it's a great product at a good price. Some customers also say that the price is very competitive.

"Good product." Read more

"Fast shipping, quality product at a great price." Read more

"...I believe it was exactly as labeled, not past expiration etc, and of quality...." Read more

"It helps my dog. Good product" Read more

69 customers mention60 positive9 negative

Customers find the pet pest control product easy to apply. They say it's convenient and works great.

"It good n easy to use." Read more

"...It’s one of a few products that kill fleas AND ticks. Application is easy - just squeeze the product between the shoulder blades ensuring you get..." Read more

"It works good on fleas. Easy to apply and a good price." Read more

"Easy to use, easy to apply. Works great. Our dogs like to get in amongst the shrubbery, and this keeps them free of ticks and fleas...." Read more

689 customers mention349 positive340 negative

Customers are mixed about the performance of the pet pest control product. Some mention that it works fantastic, is highly effective, and has no issues. However, others say that it's not working like it use to and is not as effective anymore.

"works great always buy this product good price" Read more

"I have used Frontline a lot of year's. However it's not working like it use too. I'm very disappointed...." Read more

"I live in the country so we have a lot of fleas. This works great for a couple of months and then it seems to become less affective so I rotate..." Read more

"It does not work that well. They still have fleas and are itching." Read more

391 customers mention251 positive140 negative

Customers are mixed about the flea/tick control of the product. Some mention it's one of few products that kill fleas and ticks, and experience no issues with flea infestation. However, others say that the flees are worse than ever now, and the product doesn't work as expected.

"...I'm happy I did! No more fleas! Price is affordable too! Thanks for that!" Read more

"...Boy was I wrong.The fleas are worse than ever now. Despite dosing every 2 weeks!..." Read more

"I use this on my German shepherd. Never had a flea tick problem." Read more

"...several days since we first applied it and it seems to have gotten rid of the pests. The only concern is that it does seem to dry out my pets skin." Read more

46 customers mention17 positive29 negative

Customers are mixed about the effect on skin. Some mention that the product has not caused any skin irritation or discomfort for the dog, while others say that their dog itches non stop and there are fleas all over her.

"It does not work that well. They still have fleas and are itching." Read more

"Skin is more supple and will soak it up better" Read more

"...upset when you first put it on them, there is a slight burning sensation when first applied, but it goes away after a few minutes...." Read more

"...they have no hair on half their body and have nothing but red skin filled with bites and sores and the fleas just keep getting worse...." Read more

36 customers mention24 positive12 negative

Customers are mixed about the durability of the pet pest control. Some mention that it's long-lasting, reliable, and strong. However, others say that it didn't seem to last long and wore off after 3 weeks.

"Product itself Works wonderful I have had no issues, lasts most of the four week time span!" Read more

"Three weeks in on six animals and all of them are still suffering. Shaving one of our pups just now found multiple live fleas...." Read more

"This used to be a very reliable product. Especially in New England with the high deer tick population. Not anymore. I have a 100 lbs. German Shepard...." Read more

"...Frontline is waterproof and will last the entire month as promised...." Read more

26 customers mention15 positive11 negative

Customers are mixed about the effect of the pet pest control product. Some mention it's the best way to keep the doggies happy and keeps fleas and ticks off, while others say it has done nothing for their pets and they now have an infestation. Some animals have a really bad reaction that manifests as rash throughout the body.

"...The big secret is that you CAN use it for cats too. I called the Merial company to get real answers...." Read more

"...The animals were still infested. I actually shaved the dog because she chewed her rump bloody!!!..." Read more

"My dog is 14. Been using this for years and there has never been a flee on him! Ticks shrivel up and die immediately! This product is very good!" Read more

"Worked great the first time but upon second dosing it had no effect on my dog or the third time" Read more

Crushed Box
4 Stars
Crushed Box
Product works fine, just wondering why a dinosaur sat on it before it arrived to me.
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Top reviews from the United States

lyndaleamac
5.0 out of 5 stars Works well
Reviewed in the United States on April 27, 2024
Size: 3 CountVerified Purchase
I haven't used frontline for quite a few years because it wasn't working for my dogs. However, I thought I would give it a go and try again. I'm happy I did! No more fleas! Price is affordable too! Thanks for that!
Helpful
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pamela marvel
5.0 out of 5 stars awesome
Reviewed in the United States on April 18, 2024
Size: 3 CountVerified Purchase
works great always buy this product good price
Helpful
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elizabeth nicol
5.0 out of 5 stars no bugs
Reviewed in the United States on April 27, 2024
Size: 3 CountVerified Purchase
I use this on my German shepherd. Never had a flea tick problem.
Helpful
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Debbie Hunt
4.0 out of 5 stars Works sometimes.
Reviewed in the United States on March 18, 2024
Size: 6 CountVerified Purchase
I live in the country so we have a lot of fleas. This works great for a couple of months and then it seems to become less affective so I rotate through three different flea drops and that seems to help.
Helpful
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AzUWish
5.0 out of 5 stars Shippimg issue
Reviewed in the United States on April 28, 2024
Size: 6 CountVerified Purchase
Thisis a great prodicy. I've used it for years but usually buy from Chewy .I.have never received a box that r was open.
This one was and it concerns me about tamperimg.The tubes look okay but the box being open is not good. These boxes are sealed, they do not open just bc of being shipped.
Buy the product but beware of this shipping.
Helpful
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Deborah Martin
5.0 out of 5 stars Great product for pets
Reviewed in the United States on April 25, 2024
Size: 8 CountVerified Purchase
The vet was low on inventory, Amazon could fill immediately. Pets are protected at a better price.
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Sierra Rae
5.0 out of 5 stars Great product
Reviewed in the United States on March 29, 2024
Size: 3 CountVerified Purchase
Thank you!
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Angela Davis
3.0 out of 5 stars Frontline
Reviewed in the United States on March 26, 2024
Size: 3 CountVerified Purchase
I have used Frontline a lot of year's. However it's not working like it use too. I'm very disappointed. I'm going to have to find something else to treat my dog.
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