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FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments

4.4 4.4 out of 5 stars 80,777 ratings
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Amazon's Choice in Dog Flea Drops by Frontline
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3 Count
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Purchase options and add-ons

Brand Frontline
Item Form Stick
Scent Unscented
Age Range (Description) All Life Stages
Item Weight 1.6 Ounces
Active Ingredients fipronil and (S)-methoprene
Item Volume 339 Milliliters
Target Species Dog
Allergen Information Abalone Free
Dog Breed Size Large

About this item

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
  • Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
  • Trusted by pet owners for over 20 years**, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus.

Customer ratings by feature

Easy to use
3.9 3.9
Scent
3.5 3.5
Easy to remove
3.3 3.3
Comfort
3.2 3.2
See all reviews

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Frequently bought together

FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments
$30.02 ($10.01/Count)
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FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs., 3 Treatments
$30.02 ($588.63/Fluid Ounce)
Get it as soon as Tuesday, May 14
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FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs., 3 Treatments
$30.02 ($30.02/Count)
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From the brand

Previous page
  2. Frontline brand products logo. Protect your dog or cat with Frontline Plus flea and tick prevention

    THE #1 NAME IN FLEA & TICK PROTECTION*

    FRONTLINE Brand Products are effective topical solutions designed to help protect dogs and cats from fleas and ticks. FRONTLINE Plus and FRONTLINE Gold have formulas for dogs or cats. FRONTLINE Shield, with added mosquito repellency, is for dogs only.

  3. Frontline Plus for Dogs and Puppies has been trusted by pet owners for over twenty years
    Frontline Plus flea and tick medicine for small dogs six topical nonprescription applicators pack
    Frontline Plus flea and tick medicine for medium dogs six topical nonprescription applicators pack
    Frontline Plus flea and tick medicine for large dogs pack of six topical nonprescription applicators

    FRONTLINE Plus for Dogs

    Visit the Store

  4. Frontline Shield is formulated to repel ticks and mosquitoes. repelente de mosquitos para perros
    Frontline Shield flea and tick treatment and mosquito repellent for small dogs six month pack
    Frontline Shield flea and tick treatment and mosquito repellent for medium dogs six month pack
    Frontline Shield flea and tick treatment and mosquito repellent for large dogs six month pack

    FRONTLINE Shield for Dogs

    Visit the Store

  5. Frontline Plus for Cats and Kittens has been trusted by pet owners for over twenty years
    Frontline Plus flea and tick monthly prevention topical for cats and kittens three doses
    Frontline Plus flea and tick monthly prevention topical for cats and kittens six doses
    Frontline Plus flea and tick monthly prevention topical for cats and kittens eight doses

    FRONTLINE Plus for Cats

    Visit the Store

  6. Frontline comes in an easy to use applicator. Use spring summer fall winter to kill fleas and ticks
    Frontline Gold flea and tick treatment for small dogs six month supply pack
    Frontline Gold flea and tick treatment for medium dogs six month supply pack
    Frontline Gold flea and tick treatment for large dogs six month supply pack

    FRONTLINE Gold for Dogs

    Visit the Store

  7. Frontline comes in an easy to use applicator. Apply during all seasons to prevent fleas and ticks
    Frontline Gold for Cats three month supply pack. suministro de tratamiento para tres meses
    Frontline Gold for Cats six month supply pack. suministro de tratamiento para seis meses
    Frontline Gold flea and tick protection for cats and kittens

    FRONTLINE Gold for Cats

    Visit the Store

  8. Frontline brands break the flea life cycle by eradicating adult fleas eggs and larvae. Treat monthly

  9. What is FRONTLINE?

    FRONTLINE Brand Products are effective, easy-to-apply topical flea & tick preventives. FRONTLINE Plus and FRONTLINE Gold have formulas for dogs or cats. FRONTLINE Shield is for dogs only. All FRONTLINE Brand Products feature waterproof formulas that last a full 30 days.

    Why should I protect my dog or cat from fleas & ticks?

    Fleas & ticks are a year-round threat. FRONTLINE Brand Products help protect dogs or cats from these pests and monthly use can help prevent infestations.

Next page

From the manufacturer

Smiling man playing fetch outside with healthy dog. Frontline Plus awarded Newsweek most trusted
Frontline Plus has been trusted by pet owners for over 20 years and kills fleas and chewing lice
Answers to frequently asked questions about Frontline flea and tick prevention and treatment plans

How to Apply FRONTLINE Plus for Dogs

Step one woman reading instructions on pack before applying flea and tick non prescription treatment

Step two woman holding applicator upright and away from her face before opening by snapping off tip

Step three prep dog for flea treatment application by using fingers to part fur so skin is visible

Step four place the open applicator to dogs skin and squeeze out all contents on dog

Read full instructions on packaging before use. Shown here: Size Large 45-88 lbs.

Use scissors to separate one blister. Hold applicator upright with foil side toward you and snap applicator tip off.

Part dog’s hair between shoulder blades until skin is visible.

Place applicator tip directly against exposed skin and apply entire contents directly to the skin. Do not apply on top of hair.

Pack of Frontline Plus for small dog breeds tratamiento de pulgas y garrapatas para perros pequenos Pack of Frontline Plus for medium dog breeds medicina para matar pulgas y garrapatas Pack of Frontline Plus for large dog breeds prevención de pulgas y garrapatas para perros grandes Pack of Frontline Plus for xl dog breeds control de pulgas y garrapatas para perros extra grandes Frontline Plus Cat
FRONTLINE Plus for Small Dogs FRONTLINE Plus for Medium Dogs FRONTLINE Plus for Large Dogs FRONTLINE Plus for X-Large Dogs FRONTLINE Plus for Cats
Customer Reviews
4.4 out of 5 stars
80,777
4.4 out of 5 stars
21,084
4.4 out of 5 stars
80,777
4.5 out of 5 stars
13,810
4.3 out of 5 stars
43,635
Price $55.29 $55.29 $55.29 $55.29 $55.29
Recommended pet size 5 to 22 pounds 23 to 44 pounds 45 to 88 pounds 89 to 132 pounds Cats and kittens over 1.5 pounds
Kills adult fleas, flea eggs, and flea larvae ✓ ✓ ✓ ✓ ✓
Kills ticks and chewing lice ✓ ✓ ✓ ✓ ✓
Minimum age of pet for use Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Cats and kittens 8 weeks and older
Available sizes 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose
Do not use on cats Do not use on cats Do not use on cats Do not use on cats For use on cats only

Product guides and documents

User Manual (PDF)

Product information

Feedback

FRONTLINE

FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs., 3 Treatments

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Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 5.75 x 0.75 x 4.5 inches; 1.6 ounces
  • Manufacturer recommended age ‏ : ‎ 1 month and up
  • Item model number ‏ : ‎ 72219
  • Department ‏ : ‎ Insect Control
  • Date First Available ‏ : ‎ September 2, 2004
  • Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health
  • ASIN ‏ : ‎ B0002J1FOE
  • Country of Origin ‏ : ‎ Germany
  • Customer Reviews:
    4.4 4.4 out of 5 stars 80,777 ratings

Looking for specific info?

Product Description

Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE®. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**— FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: *Data on file at Boehringer Ingelheim. **Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.

Top Brand: Frontline

Highly Rated
100K+ customers rate items from this brand highly
Trending
100K+ orders for this brand in past 3 months
Low Returns
Customers usually keep items from this brand

Important information

Safety Information

KEEP OUT OF REACH OF CHILDREN. WARNING: PRECAUTIONARY STATEMENTS - HAZARDS TO HUMANS: WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid Contact with skin. Harmful if swallowed. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash clothing that may have come in contact with the product before reuse. HAZARDS TO DOMESTIC ANIMALS: For external use on dogs ONLY. Do not use on animals other than dogs. Do not use on dogs under 9 weeks of age or weighing less than 5 lbs. Individual sensitivities may occur after using ANY pesticide product. Dogs may experience some temporary irritation at the site of product application. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of sensitivity occur and persist, contact a veterinarian immediately. If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products. Consult a veterinarian for guidance on use against Sarcoptes mites. This product is not a substitute for a prescribed heartworm preventative.nCall 1-888-637-4251, for assistance. PHYSICAL OR CHEMICAL HAZARDS: Do not allow this product to come in contact with an oxidizing agent, as a hazardous chemical reaction may occur Harmful if swallowed. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid contact with skin. Wear (specify appropriate protective eyewear such as goggles, face shield, or safety glasses). Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.

Ingredients

Fipronil (9.8%)|(S)-Methoprene (8.8%)

Directions

Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product. Do not apply to dogs weighing less than 45 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month. Frequency Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

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Details
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Price-40% $30.02
List: $49.99		-15% $46.74
Typical: $54.99		-20% $66.39
List: $82.99		-20% $66.39
List: $82.99		$14.99-27% $30.02
Typical: $40.99
Delivery
Get it as soon as Wednesday, May 15
Get it as soon as Tuesday, May 14
Get it as soon as Tuesday, May 14
Get it as soon as Monday, May 13
Get it May 14 - 15
Get it as soon as Wednesday, May 15
Customer Ratings
4.44.4 out of 5 stars80,777
4.54.5 out of 5 stars567
4.34.3 out of 5 stars1,396
4.24.2 out of 5 stars443
3.63.6 out of 5 stars32
4.54.5 out of 5 stars13,810
Easy to use
3.9
4.4
4.0
4.2
4.0
4.2
Value for money
3.0
3.8
3.2
3.0
3.1
3.4
Flavor
2.7
2.4
2.9
4.8
3.3
3.1
Scent
3.5
4.4
4.0
3.5
—
3.2
Sold By
Amazon.com
Amazon.com
Amazon.com
Amazon.com
kingmo Pet
Amazon.com
target audience
Dogs
Adult
Dog
Dog
Dog
Dogs
age range
All Life Stages
All Life Stages
All Life Stages
All Life Stages
All Life Stages
All Life Stages
scent
Unscented
No Scent
Topical
Topical
—
Unscented
form
Stick
Stick
Stick
Stick
Drops
Stick
volume
339 milliliters
8.04 milliliters
24 milliliters
3 milliliters
—
302.4 milliliters
active ingredients
fipronil and (S)-methoprene
Fipronil, (S)-methoprene, Pyriproxyfen
Fipronil, Permethrin, Pyriproxyfen
Fipronil, Permethrin, Pyriproxyfen
Fipronil 9.8%, (S)-methoprene 8.8%, OTHER INGREDIENTS 81.4%, TOTAL 100.0%
fipronil and (S)-methoprene
weight
1.6 ounces
—
0.81 ounces
0.09 pounds
—
1.6 ounces

Customer reviews

4.4 out of 5 stars
4.4 out of 5
80,777 global ratings

Customers say

Customers like the protection and quality of the pet pest control. For example, they mention it provides good protection for their dogs from fleas, ticks, lice, larvae, eggs, and mosquitoes. They also like the ease of use. That said, opinions are mixed on safety, value, flea control, comfort, and performance.

AI-generated from the text of customer reviews

1,135 customers mention969 positive166 negative

Customers like the quality of the pet pest control. They say it's a high-quality product that delivers real results and gives them peace of mind. Some say it builds complimentary characteristics you wouldn't otherwise have. They are happy to know it'd be safe to use on their dog and that it'll never have a bad reaction or side effect.

"Good product" Read more

"...Bathing the second dog tomorrow! Great results…great product!" Read more

"...Their coats are shiny, they're not scratching every two seconds, and they've even started to learn new tricks...." Read more

"trustable" Read more

490 customers mention464 positive26 negative

Customers find the pet pest control product easy to use. They mention that it's simple, convenient, and not too much of a pain to apply. They also say the application process is smooth and the impact of applying the product is almost immediate.

"Super easy to use and apply. No smell, no unusual behavior from our dog afterwards...." Read more

"Easy to use and includes stickers to add to your calendar so easy to remember when the next dose is due." Read more

"...I personally like it because no flea collars. Not too much of a pain once a month." Read more

"...This applicator was easy, simple, and in one spot." Read more

244 customers mention199 positive45 negative

Customers like the protection provided by the pet pest control product. They say it's a great product to protect dogs from fleas, ticks, lice, larva, eggs, and mosquitoes. They mention that it'd be safe to use on herding breeds and is harmless to mammals.

"...size of your dog toxicity is far easier to avoid and the product much safer for your dog...." Read more

"Product really works, easy to apply and not invasive to my dog." Read more

"Works quite well to protect are little wonder dog Daisy from fleas and ticks." Read more

"No flees here. One of the best products we have gotten for our dogs ." Read more

4,076 customers mention1,813 positive2,263 negative

Customers are mixed about the performance of the pet pest control product. Some mention it works very good on their dogs to repel fleas and ticks, while others say it doesn't seem to work that well. Some say the formula has been weakened or watered down, and it stops working about 2 weeks before the next dose.

"...Keep in mind, this does not work immediately, and the instructions even state this fact. It takes time to work...." Read more

"I have been using this brand of product for years and it works amazing, I give my dog a bath and dry her with a towel and then just let her air dry..." Read more

"...It's been several weeks now and I see no improvement. It just did not work at all. The fleas have become immune to it. Or I just got a bad batch...." Read more

"...companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price...." Read more

2,088 customers mention1,133 positive955 negative

Customers are mixed about the flea control. Some mention that it keeps fleas and ticks off well, while others say that it doesn't really go away and that their pets are still infested with flea activity.

"...manchester terrier is completely healthy and fine after usage, and pest free." Read more

"...The tick was full, like a berry, and utterly disgusting, but the product worked. The tick was dead, as promised...." Read more

"Would not go without using, prevents fleas, ticks and so on." Read more

"...I got this and put it on them. It did not kill off all fleas and eggs and such within 48 hours...." Read more

1,872 customers mention1,262 positive610 negative

Customers are mixed about the value of the pet pest control product. Some mention it's very good for the price, saves money, and is worth the cash. However, others say it'd be a waste of money.

"...exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price...." Read more

"...A good product for the price and it definitely last 30+ days." Read more

"Works as ordered. A little expensive but works" Read more

"Great product and price" Read more

225 customers mention96 positive129 negative

Customers are mixed about the comfort of the pet pest control. Some mention that the drops work well without making their pet itchy, and does not hurt their skin or fur. However, others say that the itching comes back in few days.

"...Repurchased the following month & now she is having allergic reaction. Itching & scratching. She has even lost a layer of hair...." Read more

"...They have been so peaceful and restful since we applied this. I have not seen them scratch one time...." Read more

"...developed a horrible smell as it reacted to their skin, and they began itching and scratching furiously at the application site...." Read more

"...after applying the product both are free of live fleas and look much more comfortable...." Read more

201 customers mention115 positive86 negative

Customers are mixed about the safety of the pet pest control. Some mention it's great for the dogs, easy to use, and keeps the tics off their dogs. However, others say that their dogs actually get ill when it'd applied, and has a short-term effect on the dog. They also say that it did nothing to help their dogs with fleas, and killed their unborn puppies in 2018.

"Easy to use and great for the dogs." Read more

"...The next day there was no change & the dog seemed to have even more...." Read more

"I like frontline because it can also be used on pregnant and nursing dogs and as a German shepherd breeder this is important...." Read more

"...is essentially a poison to ticks and fleas, it also has a short term effect on the dog (usually mild diarrhea)...." Read more

Works great!
5 Stars
Works great!
My dog hasn't had a flea or tic on him since I started about 3 years ago. We live in the woods, walking where every possible animial walks (even bears). My dog is so clean of bugs that indoor cat has been safe without any flea or tic treatment.
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Top reviews from the United States

JM
5.0 out of 5 stars Works, safe, but not instant results
Reviewed in the United States on April 12, 2024
Size: 3 countColor: Orange BoxVerified Purchase
Super easy to use and apply. No smell, no unusual behavior from our dog afterwards. Keep in mind, this does not work immediately, and the instructions even state this fact. It takes time to work.

By month three, after the third application our flea problem was completely gone.

Before we started using this product the fleas has gotten so bad that they were in multiple areas of the house the dog had been. Using only this product and vacuuming and cleaning regularly completely eradicated the nuisance. Most importantly, our manchester terrier is completely healthy and fine after usage, and pest free.
10 people found this helpful
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Susan J. Coler
5.0 out of 5 stars Works well for keep Ticks away.
Reviewed in the United States on April 30, 2024
Size: 3 CountColor: Purple BoxVerified Purchase
Easy to use and includes stickers to add to your calendar so easy to remember when the next dose is due.
4 people found this helpful
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loren tapp
5.0 out of 5 stars love this stuff
Reviewed in the United States on April 17, 2024
Size: 3 CountColor: Purple BoxVerified Purchase
I have been using this brand of product for years and it works amazing, I give my dog a bath and dry her with a towel and then just let her air dry then i put Frontline Plus on my dog and it lasts a while i only apply once a month or once ever month in a half,
5 people found this helpful
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Peter Suslock
4.0 out of 5 stars Your Safest Bet For A Product You Wish You Didn't Need.
Reviewed in the United States on August 18, 2012
Size: 6 CountColor: Purple BoxVerified Purchase
Allow me to caveat this review by saying out of 700 plus reviews this is the most difficult to write as I despise having to use pesticides on our dogs. That said, we live in Tick and Flea central, surrounded by deep woods and our bulldogs are in every sense of the word family and we do whatever we must to protect them. That said if you're reading these reviews your dog or dogs are your heart too and using these products is a difficult choice to make, but it's one we have to make.

On that note, it's my hope the following information has some value for you.

Frontline was first put into clinical trials in 1985 shortly after the discovery of it's active ingredient Fipronil. To it's credit Frontline has maintained the safest albeit not the most effective treatment for fleas and ticks. However, the more effective products pose a significantly greater risk to your dog.
It's a slippery slope, but in evaluating what's best for your dog by providing the highest level protection with the lowest risk Frontline and FrontLine Plus are in my opinion your best bet.

Most tick and flea products contain Permethrin which may also be listed as Lyclear or Nix as the active ingredient. Permethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ - including the brain where it can do dire damage. Thousands of dogs die every year from Permethrin. Although the FDA has mandated a minimal use not to exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price.

What makes Permethrin so dangerous is that it can't distinguish between insects and mammals which of course includes human beings. It's been known to be lethal to cats since the 1970's. In fact it's so deadly to cats that even a slight transfer from dog to cat can result in seizures, brain damage and death. Permethrin is volatile as well - meaning it's airborne properties pose a threat to all who breath it in - humans included.

Frontline on the other hand uses Fipronil. Fipronil is an insecticide.

Like any chemical of this nature it can be lethal at too high of a dose. However studies including those from the Department of Environmental Conservation have determined time and time again that as long as the amount of Fipronil is at the correct dose for the weight and size of your dog toxicity is far easier to avoid and the product much safer for your dog. Unlike Premethrin, Fipronil is absorbed into the hair follicles and oil glands only. It is not absorbed into the dogs system nor is it volatile so you and your beloved pets and children can breath easy. The second active ingredient in FrontLine Plus is Methoprene which is a long existing and time proven IGR (insect growth regulator) it's distributed exactly like Fipronil but only acts on flea and tick eggs and Larvae - this is important because it kills these vermin at the start of a new life cycle. What is more, the diseases that ticks carry now are infinitely more serious than the dreaded Lime disease - which for decades was the only concern.

Competitors to Frontline (and some Vets selling other products) claim that fleas and ticks have become resistant to Frontline - However these pests have become resistant to some degree to all pesticides and no independent research exists to confirm this claim. I can assure you I've researched this in the greatest depth.

The bottom line is this - all of these products pose a risk.

The wise choice is to minimize that risk in your effort to protect your best friend from the diseases these vermin carry. Again, these diseases can be infinitely more lethal than the ingredients of the protection. To that end your safest and most effective choice is Frontline or Frontline Plus.

In the event your pet has a bad reaction to Frontline products these are the symptoms you would see:

* Restlessness

* Itching

* Vomiting

* Difficulty Breathing

* Lethargy

Should these symptoms occur, of course take your pet to your Veterinarian or emergency clinic immediately. It should be a comfort to know that unlike the toxic ingredients in most other flea and tick control products severe reactions to both Fipronil and Methoprene are rare.
1,713 people found this helpful
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shelby Jablonski
5.0 out of 5 stars Great product
Reviewed in the United States on April 18, 2024
Size: 3 countColor: Orange BoxVerified Purchase
Would not go without using, prevents fleas, ticks and so on.
2 people found this helpful
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Christine Backus
5.0 out of 5 stars Flea protection for dogs
Reviewed in the United States on May 1, 2024
Size: 3 countColor: Orange BoxVerified Purchase
Works great. My dog is unable to take chewables because they make him sick, so this is a better alternative for him.
2 people found this helpful
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Sally
5.0 out of 5 stars Good stuff
Reviewed in the United States on May 3, 2024
Size: 3 CountColor: Purple BoxVerified Purchase
Was not left on the front porch 😔 very disappointed
One person found this helpful
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Ash Carlton
4.0 out of 5 stars No more fleas.
Reviewed in the United States on April 15, 2024
Size: 3 CountColor: Purple BoxVerified Purchase
This stuff works great. I use it on both of my dogs.
3 people found this helpful
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Top reviews from other countries

Douglas fernandes
4.0 out of 5 stars Four Stars
Reviewed in India on September 5, 2017
Size: 6 CountColor: Purple BoxVerified Purchase
It was very helpful I managed to get control of the continue scratching on her back
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Sen-Sen
4.0 out of 5 stars Good.
Reviewed in India on September 29, 2017
Size: 3 CountColor: Purple BoxVerified Purchase
It works
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